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【胶质瘤新分级】Scientific Reports:神经胶质瘤新分级

尽管现代放化疗仍然是很难可靠的预测恶性神经胶质瘤。神经胶质瘤手术切除仍是治疗的首选方法。神经外科医生已经开发出一种新程序来分析放射成像扫描,可以相对准确的预测疾病的发展
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  尽管现代放化疗仍然是很难可靠的预测恶性神经胶质瘤。神经胶质瘤手术切除仍是治疗的首选方法。神经外科医生已经开发出一种新程序来分析放射成像扫描,可以相对准确的预测疾病的发展。他们的研究结果发表在《Scientific Reports》杂志上。

胶质瘤分级

  New classification system for brain tumours
  Friedlein分级A / B(FGA / B)分类系统——是以Katharina Friedlein医生命名的,对于既得肿瘤来说手术切除是否是最好的治疗方法?这种分类系统是一种快速和精确的鉴别方式。从本质上讲,医生对肿瘤的分类是通过常规磁共振成像(MRI)扫描肿瘤在大脑中所处的位置而得出的分类结果。肿瘤不处于大脑功能区域,或是位于与大脑功能区域有一定距离的位置被分类为大脑FGA,当肿瘤接近或在大脑功能区域时被分类为FGB。
  FGA / B分类方法可能对肿瘤手术的后果有指导性,精确的、低风险和定量的方式对治疗的成功几率来说是至关重要的。这使得Friedlein分级系统可以比较容易地应用于临床实践中。目前在医学方面已经有多次实践来发展这样一个分类系统。然而,实践中大多数的方法过于复杂并且只是基于理论基础,所以使其难以在临床实践中使用它们,神经外科医生Nicolai Savaskan 说,FGA / B方法尽管非常简单,但是它可以在应用标准MRI扫描基础上使神经胶质瘤患者所接受,是高度可靠的。我们希望我们的同事在小医院神经外科也能够在日常临床实践中成功地使用它。NA集群的出现和消失,包括那些不能被转基因的物种。“我们的下一个目标是调查活体、单个细胞中不同的RNA的活性,什么调节RNA活性,比较健康组织和不健康组织与阐明基因表达机制和异常RNA活动引起的疾病。”
  原始出处
  Katharina Friedlein, Yavor Bozhkov, Nirjhar Hore, Andreas Merkel, Bj?rn Sommer, Sebastian Brandner, Michael Buchfelder, Nicolai E. Savaskan & Ilker Y. Eyüpoglu. A new functional classification system (FGA/B) with prognostic value for glioma patients. Scientific Reports, July 2015
  Although modern radiotherapy and chemotherapy are still difficult to reliably predict malignant glioma. Surgical resection of glioma is still the first choice of treatment. Neurosurgeons have developed a new program to analyze imaging scans, which can predict disease development relatively accurately. Their findings are published in the journal scientific reports.
  New classification system for brain tumours
  Friedlein classification A / b (FGA / b) system - named after Dr. Katharina friedlein, is surgical resection the best treatment for existing tumors? This classification system is a fast and accurate way of identification. In essence, doctors' classification of tumors is the result of conventional magnetic resonance imaging (MRI) scanning the location of tumors in the brain. Tumor is not located in the functional area of the brain, or is located at a certain distance from the functional area of the brain is classified as brain FGA, when the tumor is close to or in the functional area of the brain is classified as FGB.
  FGA / b classification may be helpful for the outcome of tumor surgery. Accurate, low-risk and quantitative methods are essential for the success rate of treatment. This makes friedlein grading system easy to apply in clinical practice. At present, there have been many practices in medicine to develop such a classification system. However, most of the methods in practice are too complex and only based on theoretical basis, so it is difficult to use them in clinical practice. Neurosurgeon Nicolai savaskan said that FGA / B method, although very simple, can be accepted by glioma patients on the basis of standard MRI scanning, which is highly reliable. We hope that our colleagues can also use it successfully in small hospital neurosurgery in daily clinical practice. The emergence and disappearance of Na clusters, including those that cannot be genetically modified. "Our next goal is to investigate the activity of different RNAs in living and single cells, what regulates RNA activity, and compare healthy and unhealthy tissues with diseases caused by gene expression mechanism and abnormal RNA activity."
  Original source
  Katharina Friedlein, Yavor Bozhkov, Nirjhar Hore, Andreas Merkel, Bj?rn Sommer, Sebastian Brandner, Michael Buchfelder, Nicolai E. Savaskan & Ilker Y. Eyüpoglu. A new functional classification system (FGA/B) with prognostic value for glioma patients. Scientific Reports, July 2015
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